The No. 25 Golden Eagles pounded out 16 hits, including five home runs. Meanwhile pitcher J.C. Keys only allowed WKU one hit all afternoon.
That added up to WKU taking a 13-1 pounding Sunday afternoon in eight innings at Nick Denes Field. Nationally-ranked USM (24-5 overall, 8-1 Conference USA) also grabbed wins of 6-1 on Friday and 5-0 on Saturday.
The Toppers (9-20, 3-6) have lost four games in a row, all to Top 25 opponents. WKU also dropped an 11-1 decision Tuesday at No. 2 Louisville.
The Hilltoppers are 0-6 this year when playing a ranked opponent, having lost March 14 at No.