West Ham manager David Moyes will make a "last-minute call" on whether goalkeeper Lukasz Fabianski is fit to return from a knee injury.
Southampton manager Ralph Hasenhüttl has suggested that Oriol Romeu may return after three months out because of an ankle injury.
Jan Bednarek could make his 100th Premier League appearance but Che Adams and Will Smallbone remain out.
LAWRO'S PREDICTION
Southampton are already just thinking about the summer and the big question is whether they will be able to keep hold of their star striker Danny Ings. Without him you would start to worry about them a little bit.