West Ham will continue to assess Declan Rice, Nayef Aguerd and Tomas Soucek, all of whom missed Wednesday's 3-0 defeat at Manchester City through illness.
Manager David Moyes says two additional unnamed players have also become unwell since then.
Gianluca Scamacca and Kurt Zouma remain sidelined by injuries.
Manchester United will monitor winger Alejandro Garnacho, who is building fitness after an ankle injury.
Lisandro Martinez, Raphael Varane, Donny van de Beek and Scott McTominay remain sidelined.
CHRIS SUTTON'S PREDICTION
Things can change but, right now, I think West Ham need a point to stay up.