West Ham United are expected to rotate their squad after making six changes for the Carabao Cup loss at Liverpool.
Maxwel Cornet and Nayef Aguerd could be available following illness.
Manchester United captain Bruno Fernandes returns from suspension, although Diogo Dalot serves a one match-ban following his red card against Liverpool.
The visitors must assess the condition of several players, including Anthony Martial and Victor Lindelof.
MATCH FACTS
Head-to-head
- West Ham's 1-0 win during their most recent meeting with Manchester United in May is one of only eight victories in 54 attempts in this Premier League fixture.