West Ham pair Declan Rice and Aaron Cresswell return after serving bans in Thursday's Europa Conference League tie.
Brighton's new £14.9m left-back Pervis Estupinan is in contention to make his debut.
Jakub Moder is the only absentee as he continues his rehabilitation following knee surgery.
CHRIS SUTTON'S PREDICTION
West Ham have lost their first two matches but they had a difficult pre-season with injuries, and I certainly don't think there is any reason to panic.
The Hammers will turn the corner soon, but they haven't beaten Brighton in 10 attempts since the Seagulls returned to the Premier League in 2017 and I don't see that run ending here.