West Ham will be without top scorer Michail Antonio and defender Aaron Cresswell after both suffered groin injuries in the midweek EFL Cup defeat.
That could mean a start for left-back Arthur Masuaku, who has just returned after a two-month lay-off.
Arsenal will be without Mathieu Debuchy, who will be sidelined for up to six weeks with a hamstring injury.
Olivier Giroud is doubtful with a groin problem, while Santi Cazorla faces three months out after ankle surgery.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "This is where West Ham need Andy Carroll fit and firing against Arsenal defenders who haven't relished his physical threat.