Manager David Moyes will not attend West Ham's game because of his positive coronavirus test, and will relay instructions via assistant Alan Irvine.
Issa Diop and Josh Cullen also miss out because of positive tests, but Mark Noble returns after a toe problem.
Wolves' new signing Nelson Semedo is available for his debut following a move from Barcelona.
Fernando Marcal is likely to miss out after being forced off against Manchester City with a calf injury.
Head coach Nuno Espirito Santo says several other unnamed players are injury doubts.
LAWRO'S PREDICTION
Wolves will feel they deserved something out of their game against Manchester City and, if they create as many chances as they did in that game, I don't think they will end up empty-handed again this time.