West Ham failed to reach the Europa League group stage as Astra Giurgiu condemned the Hammers to a first competitive loss at the London Stadium.
After a 1-1 away draw last week, West Ham trailed when Filipe Teixeira precisely finished a swift counter attack by the Romanian champions.
The Hammers improved after the break, with Jonathan Calleri and Winston Reid bundling their best chances wide.
Ashley Fletcher also went close, but West Ham could not force extra-time.
Reaction to West Ham's embarrassing exit
More to follow.