Sheff Utd v Tottenham (19:55 GMT)
Tottenham Hotspur
Tottenham last lifted a major trophy in 2008 but they start March fighting on three fronts.
As well as the FA Cup, they are fourth in the Premier League while they are still in the Champions League.
"If we can progress in the FA Cup then we will see what happens in the next round," said assistant boss Cristian Stellini.
"We have to try to win the game. It's an important competition, we take all the competitions seriously and we want to bring the same energy we had in our stadium to an away game.