The Metropolitan Police will deploy officers inside the London Stadium when West Ham play Stoke on Saturday.
Security has been a major issue since the Hammers moved to the ground at the start of the season.
There were ugly scenes at last week's EFL Cup match against London rivals Chelsea, despite police officers being inside the stadium for the first time.
The Football Association opened an investigation after six people were arrested and more than 200 fan faced banning orders.
Stoke will be the next visitors to the ground, and a police statement said: "The Metropolitan Police Service has a comprehensive and robust policing plan for the match on Saturday, Nov.