Antonio Conte suffered his first defeat as Tottenham boss in embarrassing fashion as Slovenian minnows Mura scored a stoppage-time winner to leave Spurs' Europa Conference League hopes hanging by a thread.
Tomi Horvat had given the hosts a shock lead with a brilliant finish in the 11th minute, before Spurs' Ryan Sessegnon was sent-off for two needless yellow cards after just 32 minutes.
Yet Conte's men improved slightly in the second-half and drew level in the 72nd minute through Harry Kane's deft finish, before Mura caught them out on the counter attack with Amadej Marosa turning Davinson Sanchez before his shot deflected off the Tottenham defender and beyond back-up keeper Pierluigi Gollini.