Cristiano Ronaldo is available for Manchester United after marking his first game since being dropped from the squad with a goal on Thursday.
Harry Maguire and Donny van de Beek made their comebacks from injury in that Europa League win but Anthony Martial remains out.
West Ham will monitor Jarrod Bowen, who missed their European victory over Silkeborg with an ankle injury.
Lucas Paqueta, Craig Dawson and Maxwel Cornet are still out.
CHRIS SUTTON'S PREDICTION
West Ham are a stubborn side who are in decent form, but I don't think their backline will be good enough to keep Manchester United out.