Chelsea could hand £70m signing Wesley Fofana his debut but deadline-day capture Pierre-Emerick Aubameyang is a doubt because of a broken jaw.
Midfielder Ruben Loftus-Cheek is nursing a hamstring injury, while Conor Gallagher returns from suspension.
West Ham's record signing Lucas Paqueta could make his full debut after a substitute appearance in midweek.
David Moyes will be without Ben Johnson, who has a hamstring problem. The Hammers manager faces a late decision on Aaron Cresswell, who has a groin issue, and Gianluca Scamacca, who is taking anti-biotics for a virus.
MATCH FACTS
Head-to-head
- Chelsea have lost just one of the last 16 home meetings, a 1-0 defeat in November 2019.