Brighton teenager Julio Enciso is set for an extended spell on the sidelines after suffering a knee injury in training this week.
Joao Pedro is in line to replace the Paraguayan, while Jakub Moder is the only other injury concern.
West Ham's latest signing Konstantinos Mavropanos will not make his debut this weekend due to a minor knock.
Fellow centre-back Nayif Aguerd is suspended, but Thilo Kehrer returns after recovering from a back problem.
MATCH FACTS
Head-to-head
- Brighton have never lost to West Ham in the Premier League, winning six and drawing six of their 12 previous meetings.