Branislav Ivanovic and Matheus Pereira will miss West Bromwich Albion's Premier League match with Tottenham on Sunday after testing positive for Covid-19.
Baggies manager Slaven Bilic confirmed both players have started a period of self-isolation after the positive tests and will miss the match at The Hawthorns.
It comes as a blow to West Brom's hopes of gaining a positive result and climbing out of the relegation zone ahead of the two-week international break.
They are currently a point adrift of safety following Monday's 2-0 defeat at Fulham and have yet to win a league match on their return to the top-flight.