Sheffield United goalkeeper Aaron Ramsdale was left out of the match-day squad as he closes in on a move to Arsenal.
Dutch understudy Michael Verrips endured a nightmare first league start as he was caught out by a long throw which deflected off Jack Robinson for the opening goal and then dropped the ball at the feet of Dara O'Shea for the second.
Mowatt added a third before Callum Robinson fired home the fourth.
More to follow