Manchester City and Arsenal are both coming off the back of embarrassing European exits, but City's will hurt more as they were ahead against Monaco. Pep Guardiola has to rouse the troops against Liverpool, who tend to disappoint against smaller clubs but should be perfectly comfortable against the Catalan and his style of play.
Arsene Wenger is under major pressure, so has to get the fans back on his side with a big win over West Brom, while Manchester United's Europa League exploits might see them tired against a team who just sacked their manager, Middlesbrough.
Champions-elect Chelsea, meanwhile, can show they can do it on a wet, windy day in Stoke.