Watford battle Wolverhampton Wanderers at Vicarage Road for seventh place in the Premier League for a chance to play Europa League next season.
The Hornets have already won both meetings with Wolves in all competition this season as they look to do the league double over them.
Elsewhere, Cardiff make the trip to Fulham as they look to continue their fight to escape relegation with only three points separating them from Brighton.
In addition, there is action from Crystal Palace and Southampton who host Everton and Bournemouth, respectively.