Liverpool will aim to keep pace with the top four when they travel to Brighton and Hove & Albion at the Amex Stadium as one of six matches kicking off at 3pm.
Along with the Reds in trying to break into a Champions League spot are Tottenham Hotspur who hope to climb out of a slump in form when they visit Watford.
Sam Allardyce takes charge of Everton for the first time when his team host Huddersfield Town, while Alan Pardew is also in his first match as West Bromwich Albion boss as the Baggies entertain his former side Crystal Palace.