Watford's Turkish midfielder Ozan Tufan will undergo a fitness test after sustaining a leg injury on international duty.
Francisco Sierralta is sidelined with a hamstring issue, while Juraj Kucka serves a one-match ban following his dismissal versus Arsenal.
Suspended Manchester United midfielder Paul Pogba suffered a thigh injury while on duty with France.
Luke Shaw, Edinson Cavani and Scott McTominay will be assessed.
LAWRO'S PREDICTION
The international break was the first time in weeks I didn't hear on a daily basis about how close Manchester United boss Ole Gunnar Solskjaer is to being sacked.