Watford's Isaac Success will not make his Nigeria debut in their 2018 World Cup qualifier against Zambia after picking up an injury.
The 20-year-old had been named in the Nigeria squad for the first time, having played at youth level and helped to win the 2013 Under-17 World Cup.
Chelsea winger Victor Moses (hamstring) and Mainz defender Leon Balogun (muscular injury) are also out.
Godwin Obaje, Chisom Egbuchulam and Uche Henry Agbo are their replacements.
Success appeared to be in line to make his Super Eagles debut, particularly after he came off the bench to score for Watford and earn them a draw against Bournemouth on Saturday.