Manchester United interim manager Ralf Rangnick will provide a fitness update on his squad later on Friday.
Edinson Cavani and the ill Scott McTominay both missed Wednesday's game against Atletico Madrid.
Watford's Joshua King exacerbated a back problem during the midweek defeat by Crystal Palace and will be assessed.
Joao Pedro and Juraj Kucka could both return following a two-match absence, while fit-again midfielder Peter Etebo may be involved.
LAWRO'S PREDICTION
Watford won 4-1 when these sides met in November, which was the end of Ole Gunnar Solskjaer as Manchester United manager.
Three months on and United still have issues.