It's derby day in Liverpool, London and Manchester this weekend with the biggest of the lot at the Etihad Stadium where Pep Guardiola's City can clinch the Premier League title against United.
There's also a few teams fighting for their lives at the other end.
Here's our game-by-game guide to the latest round of fixtures and the rest of the best bets this weekend.
In 11 games against the top six this season, Everton have shipped 30 goals, scoring just six across eight defeats and three draws. Fair enough, there was an early-season draw at Man City and a 1-1 at Anfield but it’s a rotten record that can’t be dressed up.