League One side Rochdale will be hoping to cause an upset in one of today's early kick-offs as they host Newcastle at Spotland.
Steve Bruce's side will be hoping for a lengthy cup run after they were knocked out in the fourth round by Watford last season.
Fellow Premier League side Burnley are also in action as they face League One Peterborough United.
Birmingham vs Blackburn, Millwall vs Newport and Rotherham vs Hull are among the other games kicking off at 12.31pm.
Follow all the action with Sportsmail's DAN RIPLEY.