David Luiz and Tiemoue Bakayoko start for Chelsea against Watford despite picking up knocks during Wednesday's 3-3 draw with Roma in the Champions League.
Antonio Conte makes two changes to that team, with Antonio Rudiger replacing Andreas Christensen and Pedro Rodriguez coming in for Davide Zappacosta in a return to the 3-4-3 system that won Chelsea the Premier League title last season.
David Luiz drops back into the centre of the defensive line after being deployed at the base of midfield against Roma, while Azpilicueta is likely to shift to right wing-back in the absence of Zappacosta.