The hosts performed exceptionally at the San Siro on Thursday night, ending a troubling run of form. But they have still not won in the Premier League since the start of February, something they will be keen to change.
Meanwhile, Watford have won their last two games and will be hoping to consolidate a position in the top half of the Premier League with a victory in north London.
Join Sportsmail's ADAM SHERGOLD from 12pm for all the build-up and action.
It's been a real rollercoaster for Arsenal fans in recent weeks and months, with more downs than ups.