The Africa Cup of Nations begins next month, with over 30 Premier League players set to miss several weeks of the season as they head to Cameroon.
Watford will lose the most players - five - while Arsenal and Leicester City are set to say goodbye to four players.
Liverpool will lose three - including forwards Mohamed Salah and Sadio Mane - as will Crystal Palace.
Chelsea are going to be without keeper Edouard Mendy, who could miss the Fifa Club World Cup and league games against Liverpool, Manchester City and Tottenham, among others.
Leeds, Newcastle, Norwich and Tottenham are the only clubs not to lose anybody.