Prairie View scored on its first three possessions, but held Houston Baptist to just three second-half points. Jaden Stewart scored on a three-yard run with 5:07 to play in the third quarter to put the Panthers ahead for good, 30-27.
It was the first meeting between the schools.
Blaise Bentsen threw for three first-half touchdowns for the Huskies (0-3), who led 24-23 at intermission, but didn't play in the second half.
Jawon Pass threw for two touchdowns to lead Prairie View (2-1).
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