The Cougars stopped the run briefly and then Jabari Walker scored eight and Wright added six of Colorado's 14 straight points to build its biggest lead at 66-48.
D’Shawn Schwartz added 11 points and Walker had nine. Wright added seven rebounds and five assists.
Isaac Bonton scored nine of his 21 points in the first eight minutes of the game while the Cougars (9-6, 2-6) made nine of their first 10 shots and jumped to a 23-5 lead. The Buffaloes made 2 of 11 shots during the same stretch.
Noah Williams added 16 points and Dishon Jackson had 10 for Washington State, which had its losing streak extend to five games.