Week 16 of the 2021 NFL season kicks off with a game between two teams likely headed to the playoffs this year. The San Francisco 49ers (-3.5)
have won 5 of their last 6 games and currently is the 6th seed in the NFL. They are still trying to win the NFC West, but are two games behind both the Rams and Cardinsls. The Titans are in first place in the AFC South, but they will have to hold off the Colts who are only one game behind them.
Injury Report
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Matchup: San Francisco 49ers(8-6) vs Tennessee Titans (+3.