The big matchup of Week 10 in college football featured the 3rd-ranked Penn State Nittany Lions taking on the 4th-ranked Ohio State Buckeyes. A mostly defensive battle between Big Ten foes saw the Buckeyes come out on top and replace the Nittany Lions in the rankings. Iowa State and Pittsburgh suffered their first losses of the year to Texas Tech and SMU, respectively. Clemson and Texas A&M had been rising in the rankings, but that came to the halt as both lost. Clemson was taken down at home by Louisville while Texas A&M fell on the road to South Carolina.