Unfortunately, Virginia Tech is no stranger to being on the wrong side of an upset. In fact, the Hokies have been the subject of three major college football upsets. The most recent was suffered this past weekend when the 0-3 Old Dominion Monarchs defeated the Virginia Tech Hokies, 35-49. This defeat was particularly humiliating because it represents the largest upset since ESPN has provided its Football Power Index (FPI). As far as the 14-year history of FPI is concerned the 28.5-point underdog Monarchs defeating the Hokies is the largest points upset the index has witnessed.