The Hoos need to win out in order to make a bowl game and save Mike London's job. Believe what you may about Craig Littlepage and company, but a 4th consecutive losing season will end Mike London's Virginia career. Considering he hasn't won a game on the road in 3 years, winning out would be quite an accomplishment.
The Cardinals, on the other hand, are 5-4 and need just one more win to secure a bowl berth. This, however, is their last home game and their easiest remaining contest. So expect Louisville to come out with a lot of energy and confidence.