Virginia goes from playing against a school its head coach once coached to competing against one of the most famous players in school history.
Storylines abound for No. 10 seed Virginia, which in the first round of the NCAA Tournament beat California, the school Cavaliers coach Joanne Boyle coached at previously.
The Cavaliers must face Dawn Staley's No. 2-seeded South Carolina team on Sunday at Columbia, S.C.
Staley, a Hall of Famer, led Virginia to three Final Fours and a championship game appearance during her career with the Cavaliers from 1989-92.
"It's not about her, it's about the basketball game," Virginia guard Jocelyn Willoughby said.