Virginia started its NCAA Tournament run off with a bang, dismantling the Hampton Pirates on the way to a 36 point victory. After falling behind 10-7 just over six minutes into the game, the Hoos scored 11 consecutive points and ran away with the game against the 16 seed in the Midwest to set up a second round game with Butler.
| Virginia | Hampton | |
| Final PPP | 1.35 | 0.75 |
| Shooting (eFG%) | 65.5% | 33. |