The second Final Four matchup on Saturday will feature a pair of No. 1 seeds when Villanova battles Kansas in San Antonio.
The winner will meet the Michigan-Loyola-Chicago winner in the national championship game Monday night.
Villanova (34-4) defeated Texas Tech 71-59 in the East region of the Elite Eight while Kansas (31-7) ousted Duke 85-81 in an overtime thriller in the Midwest.
It's the sixth Final Four appearance for the Wildcats and the second in the last three years. They captured the national title in 2016 for the program's second championship. One more victory would tie the 35 wins accomplished by the 2016 team.