Villanova had little trouble dispatching seventh-seeded Marquette 94-70 in the quarterfinal round of the Big East tournament.
The next step looks to be much more challenging.
The second-seeded Wildcats (28-4) will face No. 6 seed Butler (20-12) in the semifinals Friday night at Madison Square Garden.
It will be the 20th time in program history that the Wildcats reached the semifinals of the Big East tournament.
Villanova has won nine of its last 10 Big East tournament games with the lone loss coming to Seton Hall in the championship game of the 2016 event.
Butler won its first Big East tournament game in five tries thanks to a tip-in by Tyler Wideman with 3.