USC has never lost to Colorado.
Over the teams’ previous 10 meetings, it is undefeated, and lately, it has not been close.
Since the Buffaloes joined the Pac-12 Conference in 2011, the Trojans have outscored them by 118 points over five games.
This time threatens to be different.
Colorado sits as a ranked team for the first time since 2005, at No. 21 in the AP poll, and atop the South division standings after two wins to begin its conference schedule, emerging as one of the season’s early surprise stories.
“One of the things we’ve seen is the parity of this league,” USC coach Clay Helton said this week.