Valencia welcome Villarreal to Mestalla on Thursday evening with a 3-1 lead from the first leg of their Europa League quarter-final.
Marcelino's side scored twice in injury time at the Estadio de la Ceramica last week to put themselves in the driving seat in this tie, with the Yellow Submarine once more conceding important late goals.
Javi Calleja's side are very much involved in the La Liga relegation battle and given the result from the first leg, the coach could choose to prioritise their weekend league fixture against Leganes.