The Americans will face Ecuador and Bolivia ahead of June's Copa America Centenario, and will play an important qualifier next September in Jacksonville.
The U.S. national team announced a pair of Copa America Centenario warm-up matches and a World Cup qualifier on Tuesday.
The Americans will begin their Copa America preparations against Ecuador on May 25 at Toyota Stadium in Frisco, Texas, followed by a friendly against Bolivia on May 28 at Children's Mercy Park in Kansas City, Kansas.
After June's Copa America, which will take place across the United States, the Stars and Stripes will play their final match of the semifinal round of 2018 World Cup qualifying on Sept.