The strikers will be asked to carry a heavy load with Clint Dempsey and Michael Bradley both out of action.
Bobby Wood and Jozy Altidore will lead the line for the U.S. national team against St. Vincent and the Grenadines.
Altidore and Wood will be supported from the midfield by Fabian Johnson, Alejandro Bedoya and Graham Zusi, with Kyle Beckerman taking up the fourth midfield spot. Normal U.S. mainstays Clint Dempsey missed this round of qualifiers with an irregular heart beat while Michael Bradley is suspended for the match. Bradley will be eligible to return for the USA match against Trinidad and Tobago Sept.