Cristiano Ronaldo returned to the Portugal team on Friday evening, yet the captain was unable to inspire the side against Ukraine.
The European champions' first game in qualifying for the 2020 edition of the tournament ended 0-0 and Fernando Santos will be hoping his side improves on Monday night against Serbia.
Serbia are likely to be Portugal's main competition in Group B and the Balkan nation earned a creditable draw in a friendly in Germany last Wednesday.
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Portugal remain unbeaten in competitive fixtures on home soil since 2014 and William Hill offer the hosts at 6/10 (1.