Nigerian pair Enugu Rangers and Enyimba were both defeated in Caf Confederation Cup action on Sunday during a bruising day for the NPFL duo.
Rangers took a 1-0 lead at home against Egyptian moneybags Pyramids when Ibrahim Olawoyin opened the scoring in the 29th minute, but after losing Tope Olusesi to a red card, the hosts crumbled.
Mohamed Farouk converted a penalty after the break, before Amor Layouni and Islam Eissa added further goals for Sebastien Desabre’s side.
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In Group A’s other opening clash, Pyramids’ fellow Egyptians Al-Masry secured a 3-2 victory away at FC Nouadhibou of Mauritania.