Teenage standouts Weston McKennie and Josh Sargent were among the new faces called in, while Christian Pulisic was left off the U.S. roster.
The U.S. national team's youth movement in the wake of missing out on the 2018 World Cup is officially underway.
Schalke midfielder Weston McKennie, U.S. Under-17 and Under-20 standout Josh Sargent, and New York Red Bulls midfielder Tyler Adams headline a group of nine players 22 and younger called in as part of the 21-man U.S. squad that will face Portugal in a friendly on Nov. 14 in Leiria, Portugal.
Caretaker U.S. coach Dave Sarachan has called in an inexperienced group that includes just six players who were on the squad for the team's World Cup qualifying loss to Trinidad & Tobago in October, a defeat that cost the United States a place at the 2018 World Cup.