Christian Pulisic, John Brooks and Timothy Chandler will face Mexico for the first time in Friday night's World Cup qualifier.
All three were named in the starting lineup for the game in Columbus, Ohio.
Brooks will play in his first World Cup qualifier, though he has 27 caps and previously played in the 2014 World Cup in Brazil.
DeAndre Yedlin and Alejandro Bedoya are notable names among the midfielders on the bench.
Two years after taking a self-imposed sabattical, Tim Howard has regained his No. 1 spot and starts in goal.
The full U.