Chelsea have closed their academy building and instructed players and coaches to stay at home for a week after an outbreak of 20 cases hit the club.
Frank Lampard's first-team squad and Emma Hayes' women's side will be unaffected due to separate bubbles being implemented at Cobham.
However, the Premier League is now in discussions about rearranging the development squad match with West Ham and the Under-18s match with Brighton that were due to be played this weekend.
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Chelsea will keep the situation under constant review and those affected are self-isolating at home in line with government guidelines, with staff, players and families being kept informed.