Mikel Arteta will face former mentor Pep Guardiola after Arsenal were drawn against Manchester City in the Carabao Cup quarter-finals.
Arsenal manager Arteta spent three seasons as assistant to Guardiola during an unprecedented period of success for City before swapping jobs last December.
The sides have met twice since then, with Arsenal exacting revenge for a 3-0 Premier League defeat towards the end of last season with a 2-0 win in the 2019-20 FA Cup semi-finals.
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Arsenal beat Liverpool on penalties after a goalless last-16 tie on Thursday, while City saw off Burnley 3-0 to stay on course for a fifth Carabao Cup triumph in six years.