AmaZulu FC will welcome Kaizer Chiefs in a PSL match at King Zwelithini Stadium on Tuesday afternoon.
Usuthu are desperate to secure their first league win of the season having drawn 1-1 with Lamontville Golden Arrows in their previous match.
The Durban-based club has since parted ways with Cavin Johnson and replaced the local tactician with Serbian coach Jozef Vukusic.
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Meanwhile, Chiefs suffered their first setback of the season when they were stunned 1-0 by Polokwane City in their last encounter.
The Soweto giants will be keen to return to winning ways and get their title challenge back on track after succumbing to their maiden league defeat.