Alvaro Morata has been recalled to the Spain squad, along with Koke, while Marcos Llorente has earned a first senior call-up.
La Roja have been short of in-form central strikers in recent months but Morata has enjoyed a strong start to the season with Juventus, scoring six goals in seven appearances in all competitions, including three in his past two games.
Morata's last appearance for Spain was in a 5-0 Euro 2020 qualifying win over Romania in November 2019.
Spain manager Luis Enrique has thrown his support behind Morata on his return, saying the former Chelsea and Atletico Madrid striker has been much improved since his move to Turin.