Atletico Madrid won 3-0 at Numancia in their first game since Antoine Griezmann's controversial move to Barcelona, but the striker's replacement Joao Felix was substituted due to injury.
Diego Simeone started with five debutants, including the teenage forward, for Saturday's trip to Estadio Municipal de Burgo de Osma.
But, after taking an early blow on his right hip, the €126million signing limped off the pitch in the 26th minute and went straight down the tunnel.
New signings Kieran Trippier, Mario Hermoso, Renan Lodi and Marcos Llorente also started while Joao Felix's replacement Angel Correa hit the post shortly before half-time.